As countries strive to achieve the United Nations' Sustainable Development Goals (SDGs) by 2030, a new international study published in Nature Communications brings together 19 researchers in 13 institutions—including Jianguo "Jack" Liu, Rachel Carson Chair in Sustainability and director of Michigan State University's Center for Systems Integration and Sustainability (CSIS), former CSIS Ph.D student Zhenci Xu and two former CSIS visiting students Zhimeng Jiang and Xutong Wu—to present a comprehensive framework for understanding and managing cross-scale socioeconomic and environmental interconnections and feedback.