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2025

Новости за 21.08.2025

Plos.org 

Predicting art university students’ entrepreneurial intention: A hybrid SEM–ANN approach

by Yiliang Cao, Jie Zhang

In recent years, academics and policymakers have increasingly focused on entrepreneurial behavior among university students. While existing studies have explored the entrepreneurial intention (EI) of students from various academic disciplines, few have specifically examined the EI of art university students. Based on the Diffusion of Innovations Theory (DOI) and the Theory of Planned Behavior (TPB), this study explores the factors influencing art university students’... Читать дальше...

Plos.org 

The effect of telerehabilitation on activity performance and participation in daily life in children with developmental coordination disorder: A randomized controlled trial

by Mazlum Uruc, Burak Menek

Background

Developmental Coordination Disorder (DCD) is a neurodevelopmental condition that adversely impacts motor skills, sensory processing, and daily activity participation. Telerehabilitation has recently emerged as a promising method to improve therapy access and foster family involvement. This study investigated the effects of integrating telerehabilitation with sensory-based intervention on motor performance, sensory processing, and participation in children with DCD. Читать дальше...

Plos.org 

The potential impact of declining development assistance for health on population health in Malawi: A modelling study

by Margherita Molaro, Paul Revill, Martin Chalkley, Sakshi Mohan, Tara D. Mangal, Tim Colbourn, Joseph H. Collins, Matthew M. Graham, William Graham, Eva Janoušková, Gerald Manthalu, Emmanuel Mnjowe, Watipaso Mulwafu, Rachel E. Murray-Watson, Pakwanja D. Twea, Andrew N. Phillips, Bingling She, Asif U. Tamuri, Dominic Nkhoma, Joseph Mfutso-Bengo, Timothy B. Hallett

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Plos.org 

Decoding decision-making behavior from sparse neural spiking activity

by Yuhang Zhang, Tao Sun, Boyang Zang, Sen Wan

Decoding animal decision-making behavior from neural spike data emerges as a particularly challenging problem in neuroscience. To address this, we have devised a decision-making decoding model, incorporating a channel attention bi-directional long short-term memory network (CA-BiLSTM), with the aim of effectively parsing sparse neural spike data across multiple brain regions. Notably, the attention mechanism embedded within this model serves... Читать дальше...

Plos.org 

Improving cell-type composition inference in spatial transcriptomics with SpaDAMA

by Lin Huang, Xiaofei Liu, Fangfang Zhu, Wenwen Min

Accurate determination of cell-type composition in disease-relevant tissues is essential for identifying potential disease targets and understanding tissue heterogeneity. Most current spatial transcriptomics (ST) technologies lack single-cell resolution, which makes precise cell-type composition identification challenging. Several deconvolution methods have been developed to address this limitation by relying on single-cell RNA sequencing... Читать дальше...

Plos.org 

NextVir: Enabling classification of tumor-causing viruses with genomic foundation models

by John Robertson, Shorya Consul, Haris Vikalo

Motivation: Oncoviruses, pathogens known to cause or increase the risk of cancer, include both common viruses such as human papillomaviruses and rarer pathogens such as human T-lymphotropic viruses. Computational methods for detecting viral DNA from data acquired by modern DNA sequencing technologies have enabled studies of the association between oncoviruses and cancers. Those studies are rendered particularly challenging when multiple species of oncovirus are present in a tumor sample. Читать дальше...

Plos.org 

CytoSpatio: Learning cell type spatial relationships using multirange, multitype point process models

by Haoran Chen, Yangyuan Zhang, Robert F. Murphy

Recent advances in multiplexed fluorescence imaging have provided new opportunities for deciphering the complex spatial relationships among various cell types across diverse tissues. We introduce CytoSpatio, open-source software that constructs generative, multirange, and multitype point process models that capture interactions among multiple cell types at various distances simultaneously. On analyzing five cell types across five tissues, our... Читать дальше...

Plos.org 

Early epidemiological characteristics explain the chance of population-level virus persistence following spillover events

by Clara L. Shaw, David A. Kennedy

Spillover of viruses into novel host species occurs frequently. Often, spillover results in dead-end infections in novel hosts, sometimes, in stuttering transmission chains that die out, and rarely, in large epidemics with sustained transmission. If we could identify early which outcome will occur following a spillover event, we could more appropriately invest in efforts to surveil, respond to, or prevent disease emergence. Our goal was to identify early... Читать дальше...

Plos.org 

Why are there so few pathogens? Ecology and evolution in pathogen emergence

by John M. Drake

Why are there so few pathogens, and what determines their emergence? The ecological and evolutionary forces of host availability, geographic exposure, and microbial innovation will shape future human diseases. Why are there so few pathogens, and what determines their emergence? This Perspective argues that ecological and evolutionary forces (host availability, geographic exposure and microbial innovation) will shape future human diseases.




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