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Rana Healthcare Solutions LLC) BioIVT Senior Scientist Raju Khatri, MS, PhD, DABT, will discuss his recently published research which shows how pregnancy-related hormones (PRH) are important regulators of hepatic cytochrome P450 (CYP) enzyme expression and function. Using a sandwich-cultured human hepatocyte model, Dr. Khatri's research team showed that exposure to PRH can significantly increase concentrations of CYP3A4 and other CYPs, resulting in a dose-dependent increase in nifedipine metabolism. Nifedipine is often prescribed during pregnancy to manage hypertensive disorder.
