Salt smashes ton as England set 268 as target for West Indies
Salt had hit an unbeaten ton in England's victory in Grenada on Saturday and carried on where he left off as he took the attack the hosts from the outset in emphatic fashion.
Salt put on 117 in the opening partnership with skipper Jos Buttler before the latter was removed for 55 when he was caught in the deep by West Indies captain Rovman Powell off Jason Holder.
Will Jacks helped maintain the momentum with 24 from nine balls as part of a rapid 56-run partnership and Liam Livingstone ensured the run-rate never faded with 54 from 21 balls.
Salt was finally bowled by Andre Russell in the penultimate over after striking ten sixes and seven fours in his entertaining innings.
England's tally was second-highest innings score in a match between full member nations.
Powell had put England in to bat after winning the toss with his team 2-1 up in the five-match series.
A victory for England would set up Thursday's match as the series decider.