Protests in Iran, driven by economic issues, have spread nationwide, challenging the country's theocracy. Activists reported Thursday that Wednesday saw the most intense demonstrations, reaching rural towns and major cities. The U.S.-based Human Rights Activists News Agency said the violence has killed at least 38 people and authorities have detained over 2,200. The protests increase pressure on Iran's government and Supreme Leader Ayatollah Ali Khamenei. Authorities haven't yet fully cracked down. Iran's exiled Crown Prince Reza Pahlavi has called for protests, testing his influence. The protests are the largest since Mahsa Amini's death in 2022.