In the Research Article “Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis” by Z. Zhang et al., there were inadvertent image duplications in Figs. 4F, 6F, and S7. In Fig. 4F, the Lgr5 smFISH staining of 3-week wild-type and Ednrb−/− mouse colon was inadvertently duplicated from the 2-week group shown in Fig. 3H. In Fig. 6F, the 40× image for HSCR colostomy rectum stained for PDGFRα/MMP1/DAPI did not match the corresponding 10× image. In fig. S7, the image representing HSCR-derived organoids on day 0 was incorrect and duplicated from the images shown in Fig. 7J. Figures 4F and 6F and fig. S7 have been updated with the correct images. The other data and the conclusions in the paper are not affected.