Fly-half Edwards to make first start for Wales against Japan
Ospreys' Edwards replaces Sam Costelow at number 10 for his third cap as Wales look to avenge their 24-19 defeat to Japan last week in Kitakyushu.
It was Wales's 18th straight loss, extending a record for a Tier One country in the professional era.
Sherratt made four changes to his starting line-up, with Freddie Thomas coming in at lock after Ben Carter was ruled out following a head injury in the first minute of last week's game.
Aaron Wainwright replaces Taulupe Faletau at No.8 in a side again captained by hooker Dewi Lake. Archie Griffin takes over at tighthead prop from Keiron Assiratti.
Uncapped trio Christian Coleman, Reuben Morgan-Williams and Keelan Giles were all named on the bench.
Wales (15-1):
Blair Murray; Tom Rogers, Johnny Williams, Ben Thomas, Josh Adams; Dan Edwards, Kieran Hardy; Aaron Wainwright, Josh Macleod, Alex Mann; Teddy Williams, Freddie Thomas; Archie Griffin, Dewi Lake (capt), Nicky Smith.
Replacements: Liam Belcher, Gareth Thomas, Christian Coleman, James Ratti, Taine Plumtree, Tommy Reffell, Reuben Morgan-Williams, Keelan Giles.