Using a tool to solve a protein's structure, for most researchers in the world of structural biology and computational chemistry, is not unlike using the Rosetta Stone to unlock the secrets of ancient Egyptian texts. Once a protein's structure has been discovered or defined, one can infer crucial information about its function or, in a diseased state, its dysfunction. While researchers have been pursuing the quest of solving protein structure for decades, advancing tools and computing technologies offer a new frontier for this work.