Serie A official line-ups: Roma vs. Sassuolo
Roma look to Paulo Dybala, Matias Soulé, Evan Ferguson and Kostas Tsimikas amid an injury crisis as they host stuttering Sassuolo.
It kicks off at the Stadio Olimpico in Rome at 17.00 GMT (18.00 CET).
The Giallorossi were caught by Juventus in joint fourth place and Como were three points behind with a game in hand going into this weekend, so the pressure is building.
Gian Piero Gasperini has a reduced squad for his 900th professional match as a coach, because while Gianluca Mancini and Mario Hermoso return from suspension, Bryan Cristante is now banned.
Artem Dovbyk scored in the 2-0 win over Lecce midweek and immediately suffered another muscular injury, so he is out with Lorenzo Pellegrini, Leon Bailey and Pierluigi Gollini.
Wesley has recovered from flu symptoms, but is only fit for the bench, giving Tsimikas a rare start.
Neil El Aynaoui and Evan Ndicka are still at the Africa Cup of Nations.
Sassuolo have stuttered lately and are without a win in five Serie A rounds, managing just three stalemates, even if some of those were against Milan and Bologna.
Fresh off a 3-0 defeat to Juventus, they lost Kristian Thorstvedt to a shoulder injury during that game, joining Fali Candé, Domenico Berardi, Cristian Volpato, Filippo Romagna, Daniel Boloca and Edoardo Pieragnolo on the treatment table.
Woyo Coulibaly is at AFCON too, so options are limited, Alieu Fadera completing the trident with Andrea Pinamonti and Armand Laurienté.
Italy Under-21 international Luca Lipani gets the nod in midfield.
Roma vs. Sassuolo line-ups
Roma: Svilar; Ghilardi, Mancini, Hermoso; Celik, Pisilli, M Kone, Tsimikas; Dybala, Soulé; Ferguson
Sassuolo: Muric; Walukiewicz, Idzes, Muharemovic, Doig; Lipani, Matic, I Kone; Fadera, Pinamonti, Laurienté