by James E. Truscott, Julia C. Dunn, Marina Papaiakovou, Fabian Schaer, Marleen Werkman, D. Timothy J. Littlewood, Judd L. Walson, Roy M. Anderson
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by Vida Ami Kukula, Eleanor E. MacPherson, Irene Honam Tsey, J. Russell Stothard, Sally Theobald, Margaret Gyapong
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by Dennis W. Juma, Peninah Muiruri, Krista Yuhas, Grace John-Stewart, Ronald Ottichilo, John Waitumbi, Benson Singa, Christina Polyak, Edwin Kamau
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by Matías Fassolari, Guillermo D. Alonso
Aurora kinases constitute a family of enzymes that play a key role during metazoan cells division, being involved in events like centrosome maturation and division, chromatin condensation, mitotic spindle assembly, control of kinetochore-microtubule attachments, and cytokinesis initiation. In this work, three Aurora kinase homologues were identified in Trypanosoma cruzi (TcAUK1, -2 and -3), a protozoan parasite of the Kinetoplastida Class. The genomic... Читать дальше...
by Gokul Raj Kathamuthu, Saravanan Munisankar, Rathinam Sridhar, Dhanaraj Baskaran, Subash Babu
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by Melissa J. Gladstone, Jaya Chandna, Gwendoline Kandawasvika, Robert Ntozini, Florence D. Majo, Naume V. Tavengwa, Mduduzi N. N. Mbuya, Goldberg T. Mangwadu, Ancikaria Chigumira, Cynthia M. Chasokela, Lawrence H. Moulton, Rebecca J. Stoltzfus, Jean H. Humphrey, Andrew J. Prendergast, for the SHINE Trial Team
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by Vidya Murthy, Toma Tebaldi, Toshimi Yoshida, Serkan Erdin, Teresa Calzonetti, Ravi Vijayvargia, Takshashila Tripathi, Emanuela Kerschbamer, Ihn Sik Seong, Alessandro Quattrone, Michael E. Talkowski, James F. Gusella, Katia Georgopoulos, Marcy E. MacDonald, Marta Biagioli
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by Manuel Beiran, Srdjan Ostojic
Neural activity in awake behaving animals exhibits a vast range of timescales that can be several fold larger than the membrane time constant of individual neurons. Two types of mechanisms have been proposed to explain this conundrum. One possibility is that large timescales are generated by a network mechanism based on positive feedback, but this hypothesis requires fine-tuning of the strength or structure of the synaptic connections. A second possibility... Читать дальше...
by Vishaka Datta, Sridhar Hannenhalli, Rahul Siddharthan
ChIP-seq (Chromatin Immunoprecipitation followed by sequencing) is a high-throughput technique to identify genomic regions that are bound in vivo by a particular protein, e.g., a transcription factor (TF). Biological factors, such as chromatin state, indirect and cooperative binding, as well as experimental factors, such as antibody quality, cross-linking, and PCR biases, are known to affect the outcome of ChIP-seq experiments. However... Читать дальше...
by Chad J. Miller, Hua Jane Lou, Craig Simpson, Bert van de Kooij, Byung Hak Ha, Oriana S. Fisher, Natasha L. Pirman, Titus J. Boggon, Jesse Rinehart, Michael B. Yaffe, Rune Linding, Benjamin E. Turk
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by Foteini Protopapa, Masamichi J. Hayashi, Shrikanth Kulashekhar, Wietske van der Zwaag, Giovanni Battistella, Micah M. Murray, Ryota Kanai, Domenica Bueti
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by Annika Roth, Christina Vleurinck, Oksana Netschitailo, Vivien Bauer, Marianne Otte, Osman Kaftanoglu, Robert E. Page, Martin Beye
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Best dining room chairs, according to an interior designer.
‘For too long, elected MPPs have checked their brains and their backbones at the door on arrival at Ontario’s legislature. Too many forget their job is to bring the concerns of their riding to Queen’s Park, not the other way around.’
