A novel biosensor to detect DNA damage in real time
Double-strand breaks (DSBs) are a type of DNA damage where both strands of DNA break at the same location. They can adversely affect cell growth and functioning. Currently, DSBs are detected by immunostaining techniques, which identify markers that accompany DNA damage, such as the protein γH2AX. However, these methods are tedious, and cannot be used to detect DSBs in real time in living specimens.