Amy Schumer responds to criticism of her 'puffier than normal' face and explains she's dealing with medical issues

"Thank you so much for everyone's input about my face!" the comedian wrote in an Instagram post before explaining that she has endometriosis.

• Amy Schumer has responded to recent comments speculating on the appearance of her face.
• In an Instagram post, she said it was "puffier than normal" due to endometriosis.
• Endometriosis is a common condition that causes painful periods and sex. There's no known cure.

Amy Schumer has responded to comments speculating on her appearance during recent interviews, explaining that her face is "puffier than normal" due to endometriosis.

"Thank you so much for everyone's input about my face!" the comedian and actor sarcastically wrote on Instagram. "I've enjoyed feedback and deliberation about my appearance as all women do for almost 20 years. And you're right it is puffier than normal right now."

Taking on a more serious tone, Schumer then explained she had been diagnosed with endometriosis, which is a chronic condition in which uterine-like tissue grows in the pelvic cavity outside the uterus, according to the World Health Organization.

It causes painful periods, pain during sex, spotting, and sometimes fertility issues. There's no known cure for it. A range of medications can help manage endometriosis and its symptoms, including hormonal medicines such as GnRH-analogues and contraceptives, according to the WHO.

It affects one out of every 10 women of reproductive age, or roughly 176 million women worldwide, per the American College of Obstetricians and Gynecologists.

"There are some medical and hormonal things going on in my world right now, but I'm okay," Schumer added. "Historically, women's bodies have barely been studied medically compared to men."

She continued: "I also believe a woman doesn't need any excuse for her physical appearance and owes no explanation. But I wanted to take the opportunity to advocate for self-love and acceptance of the skin you're in."

She concluded her post by saying some days she felt "confident and good as hell," and on others she wanted to "put a bag over my head."

A representative for Schumer didn't respond to a request for comment from Business Insider.

The comedian and actor appeared on the likes of "The Tonight Show Starring Jimmy Fallon," "Good Morning America," and "The View" this week to promote the second season of her Hulu comedy-drama series, "Life & Beth," which she writes, directs, and stars in.

She shared clips of her interviews on her Instagram page, which attracted comments about her appearance. Screenshots and videos also began circulating on X, formerly known as Twitter, where she was mocked and subjected to medical speculation.

It's not the first time the "Trainwreck" star has spoken openly about her experience with endometriosis. 

In September 2021, Schumer underwent surgery to remove her uterus and appendix as a treatment for endometriosis. After the surgery, she said in a follow-up Instagram post that all of her "lifelong pain" had been "explained" and "lifted out of my body," leaving her a "changed person."

The procedure meant she would no longer be able to carry a pregnancy. Schumer already said she "could never be pregnant again" after undergoing "really tough" rounds of IVF to welcome her son, Gene David, with her husband, Chris Fischer, in May 2019.