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This JAMA Patient Page describes the symptoms, diagnosis, and treatment of peanut allergy.

This JAMA Insights discusses peanut allergy, including diagnosis, introduction of peanuts to infant diet, and immunotherapy options.

This Viewpoint from the FDA explains efforts to remove burdensome criteria for biosimilar approvals and encourage use of biosimilars over branded biologics, which could lead to greater access to biosimilars for patients and reduce treatment costs.

In this narrative medicine essay, a cardiologist struggles with an unsettling understanding of what counts as the loss of a child and what does not based on an arbitrary timeline of gestational age.

This study measures changes in patient and prescriber characteristics for direct-acting antivirals to treat hepatitis C virus infection from 2013 to 2025 in the US.

In Reply We thank Drs Jean and Lai for their interest in the ImmunoSep study and for raising the question of the potential interaction between the use of corticosteroids and precision immunotherapy, a promising therapeutic area in sepsis. The results of the ImmunoSep RCT showed that precision immunotherapy treatment for macrophage activation–like syndrome and sepsis-induced immunoparalysis may lead to significant early improvement of organ function. Precision treatment, however, should not be limited... Читать дальше...

To the Editor The recent ImmunoSep randomized clinical trial (RCT) assessed the effect of precision immunotherapy on outcomes in patients with sepsis. Although the trial demonstrated that precision immunotherapy was associated with improved organ dysfunction by day 9 compared with placebo, we have one concern regarding potential confounding.

This Rational Clinical Examination reviews the diagnostic accuracy of symptoms and signs observed in the initial evaluation of a child or adolescent who may have had a concussion.

This prospective study assesses whether adults aged 60 years or older with thyroid disease can successfully discontinue levothyroxine treatment.

Thyroid hormone medication use is common, with levothyroxine ranking among the 3 most commonly dispensed medications in the US and Europe. Older age is an independent predictor of thyroid hormone initiation. Up to 60% of adults are prescribed levothyroxine for subclinical hypothyroidism (defined as having an elevated thyrotropin [TSH] level and a free thyroxine level within the reference range) or for non–evidence-based indications and generally continue treatment lifelong. Widespread prescribing... Читать дальше...