The Blues' top-four hopes suffered a blow as they were swept aside by the Blades.
Alzarri Joseph and Shannon Gabriel shared four wickets in the final hour to peg back England.
Oli McBurnie was also on target for the impressive hosts.
Rob Cross had hit a nine-dart finish in his semi-final.
All three results are possible, with England ending day four 248 for eight - a lead of 170 runs on a wearing pitch.
The Baggies were held to a 1-1 draw by Blackburn.
Nick Pope made a string of outstanding saves.
Brentford are three points behind West Brom after Said Benrahma's double at Derby.
Borussia Dortmund will not sell Jadon Sancho this summer unless their full valuation is met, according to the club's sporting director Michael Zorc.
Barcelona's Philippe Coutinho will not make a decision on his future until Bayern Munich's 2019-20 campaign has ended, according to a report.
Summer arrival from Ajax Hakim Ziyech trains with Chelsea for the first time on Saturday afternoon.
Manchester United make a £58m offer for Inter Milan defender Milan Skriniar, according to a report.
Liverpool could sign Espanyol centre-back Leandro Cabrera on loan this summer, according to a report.
North End were unable to make the most of a dominant second-half display.
A year that started with a modicum of hope around the KCOM Stadium is becoming increasingly desperate.
Assistant manager Leam Richardson said Wigan were moving in the right direction.
The Teessiders sit two points clear of the relegation zone with three games to play.
Anthony Joshua and Mo Farah also shared part of their workouts.
Jay Rodriguez scored a 69th minute equaliser.
Goals from Dominic Iorfa, Josh Windass and Jacob Murphy secured a much-needed second win since the restart for the Owls.
Brendan Rodgers' side head south with a mathematical possibility of booking their place back in the Champions League.
Wigan lost Danny Fox to a red card.
The result left Preston two points outside the play-off positions.
Dominic Iorfa and Josh Windass also scored for Wednesday.